The US lotteries Powerball and Mega Millions have some of the biggest jackpots on offer. Millions upon millions of people play these mega lotteries every week in the hopes of winning the frequently large jackpots, and about every month someone cracks the illusive winning number to take home the multimillion jackpot prize! But is it better to choose one over the other? Will this strategy get you that jackpot prize you so desire? We compare the Mega Millions and US Powerball so you can decide for yourself.